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doi: 10.1155/2022/7888076 46 JangH

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The consideration of cysteine during these simulations were important, as cytosolic cysteine is the rate limiting amino acid precursor for synthesis of GSH, via the -glutamylcysteine synthetase (GCS) enzyme, and this is a function of its reduced concentration compared to the other precursors, glycine and glutamate

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1c,ii), but because the sidechain of Tyr78 maintains a network of hydrogen bonds stabilizing the 1-1 loop interactions with helices 2 and 10, mutation to His78 will lead to a disruption of the hydrogen bond network, stability, and dynamics

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