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Even at the best of times, the community of microbes (microbiota) in the gut is not a harmless community of symbionts: we possess a protective gut-blood barrier to keep them out of our bloodstream, and because that is not good enough, we also have a blood-brain barrier to keep them out of our brain

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In contrast, it has been reported that in the neurons of mice with Fragile X syndrome (FXS), ATP5G1, the c subunit of F 0 -ATP synthase, is abnormally upregulated

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Ziziphus jujuba Mill.) is used to treat insomnia and neurosis (Zhou and Hu, 2017), while Ye Tianshi, an ancient renowned TCM physician, used secondary formulas of Ganmai Dazao Decoction to treat mental illnesses (Guo et al., 2023)