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Antineoplastic agents such as cisplatin (Li et al., 2016a), methotrexate (Erboga et al., 2015), doxorubicin (Heeba and Mahmoud, 2016), and cyclophosphamide may cause side effects in clinical treatment due to dose-related nephrotoxicity

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Xie Y, Liu S, Chen XJ, Yu HH, Yang Y, Wang W

EGR-1 is a "master switch" gene that is rapidly activated by various stimuli, including growth factors and mechanical stress