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Furthermore, HO-1 expression can be triggered by oxidative stress, inflammation, and hypoxia, and HO-1 and its products of enzymatic activity have the effect of reducing oxidative stress and pro-inflammatory factors

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These therapies could target cytokines such as IL-1, TNF-, or IL-6 to reduce inflammation, or employ immune adjuvants to augment the immune response

Remove the product from your routine completely and avoid reintroduction unless cleared by an allergist

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Clinical evidence shows incremental improvement over microneedling alone, particularly on mature striae albae where re-initiating the healing response is more demanding