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Collectively, these observations provide preliminary data suggesting that pioglitazone may modulate metabolic pathways in early IBM, but whether this affects disease biology is unknown

These transporters and cognate accessory proteins may function as membrane-associated metallochaperones, in the regulation of transport, or in the metalation of metalloenzymes

Acromegaly is treated by reducing GH levels or GH actions to the level by which IGF-1 normalizes, and T1DM is treated by insulin until HbA1c levels normalize [1-4]

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