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HIV-associated inflammation can induce indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase-mediated tryptophan catabolism to kynurenine (KYN), branching toward kynurenic acid (astrocyte-biased, anti-excitatory) and quinolinic acid (QUIN, microglia-biased, N-methyl-D-aspartate agonist) [47]

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Samples for measurements with GSH were also supplemented with 1 U GR and 100 M NADPH to remove traces of GSSG and to maintain a highly reducing redox state

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Indeed, Cl channels and Cl transporters also help regulate -cell membrane potential and excitability, both crucial for insulin release ( channels in islet physiology (Crutzen et al., 2016