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Tesamorelin is a GHRH analog, the only peptide in its class with FDA approval (for HIV-associated lipodystrophy), and it drives fat breakdown specifically in visceral adipose tissue

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For overall weight loss, GLP-1 medications like semaglutide and tirzepatide have the strongest clinical evidence

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Identifying imbalances in these markers allows for targeted medical and lifestyle interventions that can enhance the effectiveness of peptide therapy while reducing the risk of adverse responses