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Natural Product Reports , 38 (1), 83102

Description ALC Acetyl L-Carnitine Discover the potential of ALC Acetyl L-Carnitine (ALCAR) as an essential compound involved in fat metabolism and energy production in our bodies

10.1080/19490976.2021.1892441 78 KleiberT.DavidsonG.MengusG.MartianovI.DavidsonI

Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

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Alterations in histone acetylation and DNA methylation affect the transcription of key autophagy genes such as ATG5 and LC3B