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Schrama et al., 2022), in which authors used creatine or ethylenediamine tetra-acetic acid (EDTA) enriched fish diets to either reduce parvalbumin concentration or induce apo-parvalbumin (a free calcium binding ion structural form of parvalbumin with reduced IgE-binding capacity), respectively (Figure 2)
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The agency has previously expressed concern about several of these ingredients for reasons including, for example, the potential adverse effects of higenamine on the cardiovascular system
A human GLA-specific gRNA sequence was provided by Invitrogen Life Technologies (GLA gRNA sequence: TTGGCAAGGACGCCTACCAT)
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