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The success of this approach is, in part, due to the high binding specificity of folic acid to these receptors versus the poor affinity of RFC for folic acid

This is more common in people with health issues or nutritional gaps

These labs allow detection of pre-existing contraindications (impaired kidney or liver function, subclinical thyroid dysfunction) and provide reference values for interval monitoring during the protocol

While folate is digested in the stomach and converted into its active form, folic acid is only partially processed via digestion