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When PD-L1 attaches to PD-1 on T cells, it significantly reduces subsequent signaling pathways like PI3K/Akt/mTOR and Ras/MEK/ERK, usually initiated by CD28 activation, resulting in the inhibition of T-cell metabolism and the triggering of T-cell cycle arrest [101, 102]

Activation of nrf2 by sulforaphane inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling

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Targeting fungal-specific biological pathways, such as chitin synthesis or virulence factor secretion, offers opportunities for designing highly selective and less toxic agents (Chung et al., 2025)

Optimization of Vit A and Lup concentrations for cryopreservation of bucks semen

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