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10.1016/j.plantsci.2012.01.005 Summary Keywords oxidative stress, hydrogen peroxide, dehydroascorbate, glutathione S -transferase, glutaredoxin Citation Rahantaniaina M-S, Tuzet A, Mhamdi A and Noctor G (2013) Missing links in understanding redox signaling via thiol/disulfide modulation: how is glutathione oxidized in plants

This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule

Scientists continue exploring its biological activity across numerous laboratory models involving cellular communication, tissue biology, and gastrointestinal physiology

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Standard glutathione is notoriously fragile