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While short-term fasting decreases serum IGF-I but does not affect GHBP (69), the triad of IGF-I deficiency, poor growth and pubertal delay/arrest in long term nutritional deficiency such as in anorexia nervosa is associated with low GHBP that is partly restored with weight gain (63)

The remaining 500 mcg is wasted

Peptides are generally broken down in the gut before they can reach the bloodstream

In a supportive wellness context, carefully selected peptides may be used in very small amounts to work with the body's own biology

The glucagon receptor component appears to drive much of this effect