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In C2C12 myotubes, NNMT inhibitor treatment produces concentration-dependent increases in NADH levels (50% higher at 30 M) and reduces NAD+/NADH ratios by 25-40%
One study found that mice treated with 5-Amino-1MQ had significantly lower body weight, smaller fat cells, and less overall fat mass than untreated mice , despite no difference in food intake
If you were on any dietary restrictions for other medical reasons, continue those as instructed by your doctor or dietitian
Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA
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Track progress through multiple metrics: scale weight (understanding water fluctuations affect this), body measurements at consistent points, progress photos in consistent lighting and posture, and subjective assessments of how clothing fits
