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It is important to note that many of the studies that examined the efficacy of lipoic acid in the treatment of diabetic neuropathy have been primarily conducted by one German research group and funded by the manufacturer of lipoic acid in Germany (82)

Therefore, HO-1, as a key factor in the inflammatory response, is expected to provide effective strategies for the prevention and treatment of diabetic complications and can provide novel ideas and drug targets for the prevention and treatment of clinical diseases

Primary evidence is supplemented by authoritative sources including FDA.gov, NIH.gov, MayoClinic.org, and ClevelandClinic.org due to limited recent peer-reviewed publications on FDA status and long-term safety for this specific query

(Piscataway, NJ, USA), whereas TAT (YGRKKRRQRRR) control peptide was synthesized by Biomatik (Cambridge, Ontario, Canada)