Cryotherapy risks primarily involve direct cold injury (frostbite) from excessive exposure duration or temperature
Vitamin E:A powerful antioxidant that protects cells from oxidative stress, supports skin regeneration, and aids in tissue healing and elasticity.It helps maintain healthy joint tissue and prevents premature aging of connective structures
Jung YC, et al
It also depends on how the patient responds to the initial therapy
For example, 3-HK scavenges NO [164], limiting lipid and protein oxidation, as observed in supernatants from rat cerebral cortex [163], and short-term exposure (100 M, 1 h) markedly enhances antioxidant capacity in C6 glioma cells by up to 400% [163]
When the PI3K-AKT-mTOR signaling pathway is activated, mTORC1 can inhibit ferroptosis by upregulating the expression of SREBP1(Wu et al., 2021