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Microneedle delivery systems have emerged as transformative tools for gout therapy, enabling localized and sustained drug release while minimizing systemic toxicity

Establishment of 143B subcutaneous osteosarcoma mouse model and therapeutic effect evaluation Tumor model establishment and biodistribution study of NP4 in vivo Three female BALB/c nude mice were subcutaneously inoculated with 143B human osteosarcoma cells (3 10 6 ) on the right buttock

All the other chemicals and reagents were bought from reputed manufacturers of analytical grade

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The treatment process remains brief and requires minimal invasion so patients can use it as a quick lunchtime energy boost

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