In contrast, it significantly decreased the populations of T helper type 1 (Th1) and type 17 (Th17) cells (65), which produce proinflammatory cytokines and mediate inflammation in the CNS mainly in patients with MS (66) as well as in those with EAE (6771)
In mice, administration of MOTS-c improved markers of endothelial performance, suggesting that it can enhance vascular reactivity and health
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