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In conclusion, our findings uncovered a novel physiological role for GH, which is to signal caloric deficiency to the brain, triggering important adaptive responses to conserve energy via activation of AgRP neurons

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Beyond inducing weight loss, these treatments have demonstrated benefits on obesity-related complications, including neuropsychiatric and substance use disorders, peripheral vascular disease, arthritis, MASLD, hypertension and renal disorders, positioning them as a central focus in current obesity research [3]

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Biochem J 360:116 Shu DF, Wang LY, Duan M, Deng YS, Meng QW (2011) Antisense-mediated depletion of tomato chloroplast glutathione reductase enhances susceptibility to chilling stress