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There is evidence from animal models and PD patients that neuro-inflammatory processes, triggered by reactive oxygen species (ROS), damage mitochondrial membrane permeability, enzymes, and mitochondrial genome resulting in DA cell death (82, 83)

Serotonin is a regulator of numerous physiological activities, including behavior, mood, memory, neurogenesis, embryonic development, smooth muscle homeostasis, liver homeostasis, and gastrointestinal homeostasis 17,18,19