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Barde S, et al

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Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

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Possible contributors to recurrent hives include: Frequent viral infections Stress or strong emotions Increased histamine load due to gut irritation or certain foods Environmental allergens If hives come back often or persist beyond six weeks, a doctor may recommend allergy testing, checking for underlying inflammation, or evaluating how the immune system is functioning