Funding This work was supported in part by grands from, and grands from the National Natural Science Foundation of China (82403715, 82270585, 42125707, 82400655 and U25A201), Natural Science Foundation of Chongqing (CSTB2024NSCQ-LZX0067), Major State Basic Research Development Program of China (2022YFA1103402), and grands from the Young PhD Talent Program of Xinqiao Hospital (2023YQB016 and 2024YQB070)
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Al is considered an oxidant and neurotoxic compound due to its ability to bioaccumulate in the body tissue and react with the cell compounds generating oxidative stress conditions 27
The finding that younger people with COVID-19 also are glutathione deficient and have elevated oxidative stress and oxidant damage is really surprising, because we do not normally see these defects in younger age groups
Statistical analysis Computational survival analysis of OS and DFS based on GPX4 expression was completed using a log-rank test of the survival curves generated using the KaplanMeier method
Model residue interaction analysis Interactions of peptides with receptors or RAMPs were analysed using the Dimplot module within the Ligplot + v2.24 38
