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628 Interestingly, low concentrations of TNF- can induce hepatocyte proliferation by activating YAP, whereas high concentrations trigger cell death by inducing phosphorylation and inactivation of YAP following APAP treatment

Hyperhomocysteinemia induces DNA fragmentation via poly (ADP-ribose) polymerase cleavage, an enzymatic activity effectively suppressed by melatonin

This process helps lighten skin tone, reduce pigmentation, and promote a radiant, even complexion

15 ROS include radical compounds, such as superoxide, hydroxyl radicals, and lipid hydroperoxides, and reactive nonradical compounds, such as singlet oxygen, hydrogen peroxide (H 2 O 2 ), hypochlorous acid, chloramines, and ozone

Consequently, therapeutic options that encompass compounds with multiple targets are deemed viable for addressing diseases with multifactorial causes, such as DS (Baburamani et al