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In Hashimoto's thyroiditis, due to the attack on the thyroid tissue of the patients in the early stages, the thyroid cells begin to break down and the thyroid hormone passing into the blood begins to increase

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doi: 10.1093/oxfordjournals.jbchem.a130387

That is how many years separate the 2014 Nature paper that put NNMT inhibition on the map [3] from wherever you are reading this in 2026