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Finally, modulation of the intracellular redox status through inhibition of glutathione synthesis influenced the extent of amoxicillin adduct formation with cellular proteins
This is due to several factors that differ between the controlled conditions of in vitro studies and the complex biological processes in living organisms, including interactions between different cell types, organ systems, and environmental variables (e.g., gut microbiota or circulation) that can influence how a drug works
This makes the parasite enzyme a potential target for antitrypanosomal drug design
7a, b, Cys 2 starvation as well as BSO and erastin treatment increased the percentage of cells in the G0/G1 phase with a concomitant decrease in the G2 phases, suggesting that GSH depletion induces growth arrest in RPE cells
Most conditions associated with chronic, non-healing wounds have underlying metabolic causes (Sen, 2021)
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