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[5] [6] Individuals taking certain medications may also need higher doses, including those on metformin (commonly prescribed for type 2 diabetes), proton pump inhibitors, or H2-receptor antagonists for extended periods

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This method is particularly effective for patients who have difficulty absorbing B12 from food or pills due to conditions like pernicious anemia, Crohns disease, celiac disease, or post-gastrointestinal surgery

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In simple terms: Capsules: easier, gut-focused, less direct systemic exposure Injections: more direct, stronger systemic exposure, more care required This does not mean one form is always better

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