Release of proangiogenic factors and increased hypoxia in response to vascularization blockade can lead to recruitment of endothelial progenitor cells (EPC) from the bone marrow, which contribute to tumor vascularization and have been linked to development of resistance to anti-VEGF therapy [303]
Kang SG, Park J, Cho JY, Ulrich B, Kim CH
Also, It reduces PD-1 expression on exhausted T cells, potentially reversing age-related immune decline and improving vaccine responses (315)
Chimerism following sex-mismatched allogeneic BMT in chronic lymphocytic leukemia (CLL)
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Indeed, protein glutathionylation reactions can result in a bolstering of the cells protective mechanisms, for example by enhancing GSH synthesis pathways