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The modulation of the Wnt pathway in mice leads to the development of ASD-like social deficits and changes in the production of cortical neurons [186,187,188,189]

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Its metabolism is closely linked to the transsulfurization branch (providing cysteine), the GSH-GSSG redox cycle (maintaining redox balance), and the detoxification system (completing substance detoxification), forming a complex and efficient metabolic network

The similarity in changes in GCL activity in the liver with the rebound increase in ELF GSH also point to the liver as a potential source for this GSH

Bodoy, S., Fotiadis, D., Stoeger, C., Kanai, Y