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This dual modulation allows BPC-157 to normalize nitric oxide levels whether they are pathologically elevated or depleted, providing adaptive vascular protection

Furthermore, casomorphins have been shown to directly affect the serotonergic system, independent of opioid receptor activation (Woodford 2021)

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Nitric oxide (NO) system modulation: BPC-157 interacts with the nitric oxide system, which plays critical roles in vasodilation, inflammation regulation, and tissue repair