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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

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Messaging is first-class with Signal-style Double Ratchet (1:1) and MLS for groups

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Initial protocols commonly run six to twelve weeks, with longer courses for complex or chronic cases and maintenance schedules afterward where appropriate

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